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10.1080/1061186X.2017.1419478 100 TiY.WangW.WangX.BanY.WangP.ZhangY.et al (2022)

Dimethyl fumarate induces glutathione recycling by upregulation of glutathione reductase

Moreover, mutations in the Zip7 gene have been linked to a novel autosomal recessive disease characterized by agammaglobulinemia and early-onset infections, highlighting the crucial role of Zip7 in B cell development and immune function, as confirmed through CRISPR-Cas9 mutagenesis in mice [44]

The oxidative-defence pathway: natures shield The three major endogenously produced enzymatic antioxidants: superoxide dismutase (SOD), catalase and glutathione peroxidase, provide a primary defence system against cellular damage by removing free radicals as they are produced during metabolic reactions