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Advanced DDS with precise targeting can lead to the accumulation of nanoparticles at the target site, where undesired interactions can occur, resulting in neurotoxicity mediated by oxidative stress, disruption of membrane integrity, and DNA damage (Zhang et al., 2021

Department of Energy, Basic Energy Science and the Canadian Light Source

This process is known as gene expression , the process by which information stored in DNA is used to produce a functional product, usually a protein

For instance, smaller particles with a more neutral surface charge are less likely to cause irritation and inflammation [336,337,338]

Ask yourself, does the documentation support a significant, separately identifiable E&M service