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Which has the most evidence

This leads to the loss of collagen elasticity and degradation, increase in cardiac interstitial and perivascular fibrosis and subsequently to a reduction of arterial and myocardial compliance (50, 51)

Despite this remyelination, persistent behavioral changes such as poor adaptive motor learning and motor function are apparent 47 weeks after cuprizone withdrawal, which is several weeks longer than is required for remyelination [57, 61]

This is the same general system that benzodiazepine drugs like diazepam target, but Selank acts differently: it modulates and stabilizes the system rather than flooding it, resulting in reduced anxiety without sedation or loss of cognitive sharpness

Update 30 , 614647 (2024)