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And so, uh, cold-cold its kind of nice to know that, you know, cold does a lot of things that-that-that heat also does and vice versa

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The Trojan Horse hypothesis posits that the nanoparticle form facilitates uptake, subsequently dissolving within the acidic confines of organelles like lysosomes to deliver a highly concentrated dose of toxic ions.136,151 The pH-dependent dissolution of ZnO is a classic example:ZnO(s) + 2H+(aq) Zn2+(aq) + H2O(l)While this mechanism is compelling and supported by significant evidence,152 a critical perspective acknowledges the immense difficulty in experimentally deconvoluting these two toxicity vectors

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J Am Chem Soc 123:11731183 Wu X, Gu L, Holden J, Haytowitz D, Gebhardt SE, Beecher G, Prior RL (2004) Factors in the development of a database of food total antioxidant capacity using lipophilic and hydrophilic oxygen radical absorbance capacity (ORAC FL ): a preliminary study of 28 foods