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6.5.3 Extremely limited clinical intervention Most current evidence derives from preclinical models, while interventional clinical trials specifically designed to target the ferroptosis pathway in AD patients remain scarce

Plant Arch 19:13471359 Zara S, De Colli M, Rapino M, Pacella S, Nasuti C, Sozio P, Di Stefano A, Cataldi A (2013) Ibuprofen and lipoic acid conjugate neuroprotective activity is mediated by Ngb/Akt intracellular signaling pathway in Alzheimers disease rat model

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2014;4(11):e479

The peptide binds to actin monomers and influences polymerization dynamics, affecting cytoskeletal organization crucial for cell migration, division, and structural adaptation