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Curcumin and its metabolites undergo further metabolism in the liver before being excreted into bile or distributed to tissues or kidneys via systemic circulation (92, 121)

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As monotherapy , a multicentre, randomised, double-blind, placebo-controlled and active-controlled Phase 2 dose-finding trial enrolled 706 adults with overweight or obesity (without diabetes) to once-weekly subcutaneous cagrilintide across doses of 0.3 to 4.5 mg over 26 weeks