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Baseline fatigue was also predictive of EDSS worsening in a retrospective cohort of pwMS of the New York State MS Consortium, although the study design did not allow to specifically assess and adjust the effect of depression 34

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However, as a result of their invasiveness they must be used cautiously to avoid cutaneous reactions or risk of causing PIH, especially in patients with darker skin tone (Fitzpatrick phototype IV) [25, 27, 195,196,197,198]