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Astaxanthin has been shown to increase BDNF levels studies in rodents and human cells (in vitro) Improvements in memory are observed in some studies but with variability across demographics These neurocognitive benefits may be through reduced lipid peroxidation Longevity pathways: Astaxanthin mechanistically modulates key longevity genes, including FOXO3, Sirt1, Klotho, and Nrf2

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Concerning pharmacological therapy, medicines used in the treatment of IC are those targeting the diseases confirmed etiology, including mucin substitutes and antihistamines (Amrute and Moldwin, 2007)

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PGG also reduced the expression of human proinflammatory cytokines GRO and GRO-/CXCL1 ( O - -D-galloyl glucose) from Mangifera indica L