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By integrating ketamine therapy into a comprehensive treatment plan and conducting it under medical supervision, individuals with fibromyalgia may experience significant improvements in pain management and overall quality of life

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In the context of metabolic disorders, numerous preclinical and clinical studies indicate that CGA improves insulin sensitivity, regulates blood glucose levels, lowers blood pressure, and positively affects the lipid profile by reducing LDL cholesterol and triglyceride levels while increasing HDL cholesterol [87,88,89,90,91,92,93,183]

Nrf2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression

Notably, the benefits of exercise on longevity are observed even in individuals with genetically determined longevity, such as centenarians, where the decline in lung function and sarcopenia could be counteracted by exercise programs that increase their physical capacity and health span (Venturelli et al., 2012)