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Figure 2 2.3 DPI synergizes with vincristine and MitoQ in reducing cell viability of MNA NB cells Finding synergistic drug combinations allows for combining drugs at lower concentrations, which is an important strategy for enhancing therapeutic efficacy while minimizing adverse effects

Chen YB, Li J, Quan Z, Li Y, Li Y, Tang

Inhibition of the first rate-limiting enzyme of one-carbon metabolism (PHGDH) has been shown to promote cell growth arrest, a phenomenon that occurs as a result of an accumulation of intracellular reactive oxygen species (ROS) following the inhibition of glutamine metabolism

Iron-driven redox vulnerabilities and ferroptosis pathways in breast cancer Dysregulated iron metabolism is increasingly recognised as a hallmark of breast cancer, with particularly strong implications for Triple-negative breast cancer

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