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A physical examination may reveal unsuspected diagnoses, such as Peyronies disease (PD), pre-malignant or malignant genital lesions, prostatic enlargement or irregularity/nodularity, or signs and symptoms suggestive of hypogonadism (see Table 3.3: Specific symptoms associated with LOH)

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6f and Extended Data 7d), which corresponded to a lack of rescue to sensitivity to DNA-damaging agents (Extended Data Fig