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High cerebral guanidinoacetate and variable creatine concentrations in argininosuccinate synthetase and lyase deficiency: implications for treatment

Recent research provided a deeper understanding of this notion, revealing that carbohydrate metabolism could adapt to the hypoxia condition in mild preeclampsia while a decompensation of carbohydrate metabolism reprogramming was discovered in severe preeclampsia (11) (Figure 2)

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USP13 was identified as a downstream effector of TDP-43, a protein implicated in several neurodegenerative disorders including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimers disease (AD) (Josephs et al., 2014