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Hashizume H, Falcn BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald DM

There are no validated outcome measures of RBC efficacy that assess tissue oxygenation function

In a multicenter PPMI cohort, free water in the posterior region of the SN increased in de novo PD from baseline to 1, 2, and 4 years, and changes in free water within 1 year predicted changes in the Hoehn & Yahr scale at 4 years (Burciu et al., 2017)