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By enhancing intracellular hydroperoxides, especially hydrogen peroxide, decreasing reduced glutathione concentration, increasing cysteine oxidation, and activating protein kinases, oxidant stress can enhance the activity of transcription factors, such as the nuclear factor kappa B and activator protein-1, which are involved in the expression of cell surface adhesion molecules, growth factors, immunoreceptors, and cytokines

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To overcome these limitations, ABT-263 (Navitoclax), a derivative of ABT-737, was developed as an orally bioavailable pan-BCL inhibitor (62)

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