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doi: 10.1016/j.cmet.2022.01.007

(3) It is also suggested that the ARA-290 peptide may act primarily via this IRR-mediated pathway

For elderly diabetes patients with sympathetic nerve dysfunction, the induction of hypoglycemia is reduced, and asymptomatic hypoglycemia, nonspecific neurological symptoms (improper speech, confusion of thinking, strange behavior) or direct hypoglycemic coma may occur