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For instance, glucuronidation, a phase II metabolic process catalyzed by UDP-glucuronosyltransferase (UGT) enzymes, appears to be influenced by smoking, as evidenced by the findings related to atorvastatin metabolism

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Many theories tried to explain this variation but the most accepted is that clinical response is related to serum levels of the antidepressants

Bold and bright: How tobacco companies market flavored products to appeal to youth Available in a variety of fruit, candy, dessert and cocktail flavors such as sour apple, appletini, pia colada, cotton candy and cinnamon roll it should come as no surprise that young people perceive flavored tobacco products as more appealing than non-flavored tobacco products

Mokdad et al., 2004)