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Oxidative stress impairs SIRT3 activity and transcription by regulating protein carbonylation and transcriptional function of peroxisome proliferator-activated receptor- coactivator-1, leading to mitochondrial dysfunction and activation of the mitochondrial apoptotic pathway via optic atrophy 1 to induce cell death of vitiligo melanocytes [32]

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Certain repopulated primary hepatocytes in the proximity of bile ducts reconstructed by liver ductal organoids expressed MRP2, one of the bile acid transporters, and ZO-1 in membranous area