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Description

LX7101 has undergone both Phase 1 and 2 trials for POAG and OHT starting in 2012, while ATS907 was assessed in Phase 1 and 2a trials in the same year (36)

Wetzel et al., 2019

In the presence of SF-1-dependent ArPII promoter, SF-1 activation led to the induction of CYP19A1 expression and subsequent activity ( 3 ( Figure 2A right part)