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[24] The genome encodes four open reading frames (ORFs), two of which produce a single protein due to ribosomal readthrough of a leaky UAG stop codon

[12] Health effects [edit] Even though it is less dangerous than smoking, chewing tobacco is addictive, represents a major health risk, has no safe level of use, and is not a safe substitute for smoking

When you chew tobacco, it: Results in gum recession and bone loss Causes leathery white patches and red sores that may develop into oral cancer Stains your teeth and causes bad breath Slows down the recovery speed of mouth tissues Makes you 50 times more likely to develop oral cancer E-cigarettes: Are They Safe