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Without adequate B12, myelin can break down

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The barrier functions of esophageal squamous stratified epithelium involve providing mucosal and submucosal defense against noxious intraluminal substances and regulating paracellular ion transport, which is mediated by claudins, the tetra-spanning transmembrane proteins of tight junctions, located at the apical and lateral membranes of esophageal epithelial cells