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Description

Failure to eliminate dysfunctional mitochondria leads to the accumulation of mitochondrial ROS and the release of immunogenic mtDNA, both of which act as DAMPs that activate innate immune pathways, including the NLRP3 inflammasome and type I interferon (IFN-I) signaling

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Its not a cure-all

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Lesnikov VA, Pierpaoli W

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These results are consistent with the reported finding that cAMP stimulated the phosphorylation of CREB through PKA pathway [36, 38]

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