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DighririIMAlsubaieAMHakamiFMHamithiDMAlshekhMMKhobraniFAet al

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Figure 1 Granuloma formation occurs in intrathoracic lymph nodes, lungs, skin, heart, and other organs upon contact with antigen-presenting cells (macrophages, dendritic cells, activated epithelial cells) by a triggering agent, followed by the development of unregulated autoimmune inflammation, additionally characterized by an imbalance between pro- and anti-inflammatory acquired immune cell subsets (T- and B lymphocytes) as well as regulatory T cells (79)