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Mitochondrial redox signaling and oxidative stress in kidney diseases

The toxicity of free heme is implicated in the pathology of the various etiologies of hemolytic disorders (hemolytic anemias, hemorrhagic strokes and traumas, malaria, sepsis, ischemia reperfusion injury and others [217])

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It may enhance glucose uptake in cells and reduce symptoms of diabetic peripheral neuropathy, though evidence is strongest for intravenous administration, with more modest and uncertain benefits from oral supplementation