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In summary, chemical functionalization of nanomaterials allows the modulation of epigenetic and metabolic programs in myeloid progenitors, enabling the induction or inhibition of trained immunity

The dysregulation of the interoceptive network mediated by neuroinflammation and central energy deficiency may be the core central mechanism by which PEM patients exhibit exaggerated perceptions of fatigue and pain after mild exertion, and this process is potentially regulated by the interaction between glial cell activation and neuronal mitochondrial dysfunction in the insular cortex

However, it is critically important to remember that there is no single miracle cure or quick fix for complex neuroimmune conditions like Long COVID, ME/CFS, or dysautonomia

94 Maeda, K

Morphologically, cells undergoing ferroptosis exhibit characteristics such as cell membrane rupture, mitochondrial shrinkage, and increased cell membrane density [107]