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This allows WADA to review the latest trends and scientific research to ensure that any new or existing substance or method that may meet the criteria for addition to the List are considered in a timely manner so as to protect athlete health and maintain a level playing field for all. As usual, we encourage athletes, their entourage and all stakeholders to acquaint themselves with the Summary of Major Modifications to avoid inadvertent use of substances and methods that are prohibited in sport for 2022

S -adenosylmethionine Another metabolite intimately linked to epigenetics is S -adenosylmethionine (SAM), the universal methyl donor for DNA, RNA, and histone methyltransferases

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