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In response to physical stimuli, these molecules can initiate signal transduction, modulate the intracellular ion concentration (e.g., calcium, sodium, and chloride), influence cellular tension, volume, and shape, and trigger transcriptional changes, thereby contributing to therapeutic resistance and mediating profound changes in cellular functions, including division, and migration (see sections below)

plantarum into the duodenum of healthy people increased the level of ZO-1 and occludin

In regions with cobalt deficiencies, crucial for B12 synthesis, ensuring its presence in mineral or protein/energy supplements is essential