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The activity of the mitochondrial complex I enzyme (NADH-ubiquinone oxidoreductase) was suppressed in the genomic HCV replicon cells

Free Radic Biol Med 51(9):17741788

A UNA can attach to oligonucleotide monomers to form hybrids, regulating their flexibility and thermal stability

Critically, to bridge the gap to real-world effects, the system would also incorporate a dynamic tier for in vivo evidence, distinguishing between effects validated in animal models versus human trials and noting known bioavailability limitations