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This safety profile in animal models provides some reassurance about the compounds fundamental tolerability, though extrapolation to humans requires appropriate caution

Cycling protocols vary by individual preference and injury status

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The time spent by the mouse in exploring the novel object, in comparison to the familiar object, and taking into account general exploratory/locomotor activity, is taken as a measure of learning and memory ('cognition')

As such, an effective treatment would be expected to augment striatal synaptic connectivity, protect SN neurons from underlying death inducers, and ideally stimulate the replacement of lost SN neurons from preexisting pools of neural stem cells