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[12] For most people with dietary insufficiency, oral supplementation is effective, as even in the absence of intrinsic factor, approximately 1% of B12 can be absorbed through passive diffusion

Patients see their mood improve as measured by the PHQ9 (depressive symptom index) after 6 months of treatment

Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, et al

Although severe allergic reactions are very rare, they have occurred

Moreover, the compound additively enhances the improvements in strength that come from vigorous exercise, and the data also suggests that it shortens muscle recovery time following bouts of vigorous exercise