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Although PJ and CM administration indicated a reducing tendency of MDA levels, CM showed lowest MDA contents in the serum, hepatic subcellular fractions, kidney, heart, spleen and testis (Figs

Once TMAO formation/concentration is elevated, it may increase the risks of atherosclerosis for healthy individuals ( TMAO and HF HF is defined as a group of syndromes caused by structural or functional damage that results in impaired ventricular filling or cardiac output, and which involves multi-organ and systemic neurohumoral dysfunction (89)

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This lack of efficacy may be attributed to the low plasma and sputum concentrations of NTZ and the high plasma protein binding of tizoxanide, the active metabolite of NTZ [80], highlighting the need for further pharmacokinetic optimization and clinical research to better understand its potential role in TB treatment