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Reduced BDNF signaling appears to accelerate amyloid-beta accumulation, tau phosphorylation, neuroinflammation, and neuronal apoptosis

Winner B, Desplats P, Hagl C, Klucken J, Aigner R, Ploetz S, Laemke J, Karl A, Aigner L, Masliah E, et al

Lesniak A, Salvati A, Santos-Martinez MJ, Radomski MW, Dawson KA, berg C

Authorship confirmation/contribution statement K Martino: Writing Original Draft, Data Curation, Investigation, Visualization A Nakhre: Writing Original Draft, Investigation RM Demarest: Conceptualization, Resources, Supervision (MDCK scatter assay) DM Devilbiss Conceptualization, Formal Analysis, Funding Acquisition, Methodology, Resources, Supervision, Validation, Writing Review & Editing Author(s) disclosure (Conflict of Interest) statement(s) The authors declare that they have no competing financial interests related to the work reported in this paper

Those groups pretreated with scopolamine followed by Nle1-tetrapeptide, or Nle1-tripeptide, required longer durations to locate the platform, however their search patterns were effective