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In summary, FOXO4-DRI exerts its anti-aging effects by inhibiting the binding of FOXO4 to P53, promoting P53 phosphorylation, and facilitating the translocation of p-P53 from the nucleus to the cytoplasm for its functional role

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Cells synthesize glutathione in the cytosol, rather than on ribosomes, and binding of the amino group of cysteine to the - rather than to the -carboxyl group of glutamic acid makes the bond inert towards peptidases

308 YamadaT.MitaniT.YoritaK.UchidaD.MatsushimaA.IwamasaK.et al (2000)