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When it was recognized that pellagra, a condition marked by diarrhea, dermatitis, dementia, and mortality, could be treated with foods containing NAD+ precursors, particularly vitamin B3, the clinical significance of maintaining NAD+ levels was established in the early 1900s (9). Notably, the skin does not flush with NAD+ injection, in contrast to vitamin B3 (niacin) intake, which also causes this negative effect (10). Low NAD+ levels have recently been associated with a variety of age-related ailments and diseases linked to increased oxidative/free radical damage, including diabetes, heart disease, vascular dysfunction, ischemic brain injury, Alzheimers disease, and vision loss (8, 11-17)

This follicle diameter is also positively associated with pregnancy rate and embryo survival rate [20]

GP can find treatment info for those with and without neuro symptoms in their copy of BNF book Chapter 9 Section 1.2 Some UK areas have local B12 treatment guidelines which in some cases are very out of date

Does targeted therapy make patients live longer

Its ability to promote proper tissue regeneration, not just scar formation, makes the difference