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It is well known that the function of AQP4 goes far beyond that of a specific water channel

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases

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Trans-membrane electron transfer systems using ascorbate or NADH as electron donors serve to reduce semidehydroascorbate present in secretory vesicles and in the extracellular space [26, 31]

For experiments, Apoe -/- mice were fed a high cholesterol diet (HCD, 21.2% fat by weight and 0.2% cholesterol, TD.88137, Envigo, Indianapolis, IN, USA) for a total period of eight weeks