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Heparin is often exploited as a natural polymer, as many pro-angiogenic proteins contain heparin-binding domains

study found that delivering miR-494-3p via a PLGA nanoparticle-hydrogel system significantly enhanced Achilles tendon healing in rats by sustainedly releasing miR-494-3p into tenocytes, where it suppressed CXXC4 translation, activated collagen I synthesis, improved biomechanical strength, and reduced inflammation (Wang G

These abnormalities were significantly alleviated after treatment with different LMWH formulations, especially TLH NP

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