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British Journal of Clincal Pharmacology

Fundam Clin Pharmacol 35(1):113130 Motta JR, Jung IEdC, Azzolin VF, Teixeira CF, Braun LE, De Oliveira Nerys DA, Motano MAE, Duarte MMMF, Maia-Ribeiro EA, da Cruz IBM (2021) Avocado oil ( Persea americana ) protects SH-SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules

Fe 2+ and Lipid-ROS are released from lysosomes and stimulate mitophagy, leading to a vicious cycle of iron leakage

Crucially, this iron-accumulated microenvironment imposes severe oxidative stress, creating a selective pressure that typically triggers ferroptosis [34]

Precision in medicine begins with respecting biochemistry