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By about 5:35 p.m., water is in the small intestine, moving into the bloodstream

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These changes lead to progressive symptoms, with both increasing frequency and severity of vertigo and hearing loss

For immunofluorescence staining, brain tissues were dissected out, post-fixed by 4% paraformaldehyde (PFA) for 12 h, embedded in paraffin, cut into 5 mm sections and mounted on slides for subsequent staining