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Importantly, as the chief brain source of APOE, astrocytes, especially those expressing the APOE4 allele, promote A aggregation, tau pathologies, BBB breakdown, and cerebrovascular dysfunctions (Wang M

PMID: 40858501 J Neurosci Acute Ongoing Nociception Delays Recovery of Consciousness from Sevoflurane Anesthesia via a Midbrain Circuit

Low anthocyanin plum nectar does not impact cognition, blood pressure and gut microbiota in healthy older adults: a randomized crossover trial

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5 ), including the ribosomal protein S6 kinase (S6K) and eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) that mediate mTORC1 stimulation of protein synthesis 1 , whereas it is dispensable for the phosphorylation of noncanonical substrates, such as transcription factor EB (TFEB) 6