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Some PK studies report an increased theoretical risk of toxicity with advancing age [62,63,64,65,66,67] due to prolongation of t 1/2 [62, 63], reduced paracetamol clearance [64, 67], increased paracetamol oxidation caused by a reduction in glucuronidation and sulphation capacity [65] or a reduction in liver volume [66]

However, the clinical significance of this is unclear (144)

Consistency matters more than the specific hour

SSRIs can cause adverse side effects such as headache, nausea, dizziness, fatigue, dry mouth, digestive problems, weight changes, and, rarely, suicidal thoughts

Derry S, Cording M, Wiffen PJ, Law S, Phillips T, Moore RA.Pregabalin for pain in fibromyalgia in adults