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In the context of atherosclerosis, various factors can induce the respiratory burst, including pro-inflammatory cytokines, lipids such as cholesterol, oxLDL, acute phase proteins like CRP, growth factors such as granulocyte-macrophage colony-stimulating factor (GM-CSF), circulating immune complexes, and others (Ferrante et al., 1988

Vitamin B12 is water-soluble and has very low toxicity

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For instance, the glutamine antagonist JHU083 combined with ICIs [antiPD-1/anticytotoxic T-lymphocyte-associated protein 4 (CTLA-4)] strongly enhances antitumor immunity, even eliciting responses in immunotherapy-resistant models [77]

However, on the day before the booster dose, the titers had waned to a GMT of 150 and 100 in the 100 g group and 50 g group, respectively