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Enrolling approximately 326 nondiabetic adults with amnestic MCI, this trial tests metformin XR (titrated to 2,000 mg/day) over an 18-month period, with a prespecified primary endpoint of verbal memory (FCSRT Total Recall) and a comprehensive secondary battery encompassing global cognition (ADCS-PACC), structural MRI, white-matter hyperintensity burden, amyloid/tau PET, and plasma biomarkers