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Urinary cotinine (ng/mL) was analyzed by gas chromatographymass spectrometry using a PerkinElmer Clarus 600T instrument (PerkinElmer, Waltham, MA, USA) 24

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We observed that amongst the 13 phyla, Firmicutes (50.0%), Bacteroidetes (21.7%), Proteobacteria (15.8%), Actinobacteria (6.7%) and Fusobacteria (4.7%) were the most abundant (Supplementary Table S1) and were present in all samples

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