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Authors' contributions HZ and ZJ wrote and reviewed the manuscript

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In addition, the authors would like to thank the School of Biomedical Engineering in Anhui Medical University for their generous support

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Generally, mild flushing headache may occur upon initial administration, though this commonly goes away after repeated injections Temporary nausea and upset stomach may additionally occur following administration feelings of tiredness or lethargy are also possible, as growth hormone can increase the desire for sleep as well as its quality and restorative capabilities to avoid this inconvenience (as well as to maximize its beneficial impact on nighttime production of growth hormone), many protocols call for its administration shortly before bed