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Cui X, Mi T, Xiao X, et al

10.1038/nbt.1617 80 KhanB

[7] PRN low-dose ICS/formoterol results in fewer severe exacerbations and ED visits than PRN SABA regimens regardless of baseline severity

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4b) suggests that the metabolic response is mounted quickly but sustained and enhanced over time, given that ~75% of the metabolic DEGs at 24 h are also found at 48 h (Extended Data Fig