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Description

However, side effects like nausea, dizziness, or gastrointestinal discomfort may also become more likely as the dose increases

While a single warm-to-cold transition is unlikely to cause dramatic degradation, the manufacturer has not tested repeated cycling, so they cannot guarantee stability under those conditions

Nutrients 13 ,1539 (2021)

Oral doses tend to be higher - 500 mcg to 1000 mcg twice daily - because oral bioavailability is presumably lower than injectable, though we don't have good human pharmacokinetic data