Preclinical evidence consistently demonstrates its potential to accelerate healing across multiple tissue types through mechanisms involving angiogenesis, growth factor modulation, and anti-inflammatory effects
Disclosures: Luca Fabris: Nothing to Disclose, Camilla Venturin: Nothing to Disclose, Yahima Frin-Herrera: Nothing to Disclose, Massimiliano Cadamuro: Nothing to Disclose, Claudia Mescoli: Nothing to Disclose, Umberto Cillo: Nothing to Disclose, Enrico Gringeri: Nothing to Disclose, Elena Campello: Nothing to Disclose, Mario Strazzabosco: Nothing to Disclose, Diego Calvisi: Nothing to Disclose, Antonio Cigliano: Nothing to Disclose, Paolo Simioni: Nothing to Disclose 1938 TRANSPOSON-BASED ONCOGENES INTEGRATION IN ABCB4 (MDR2)-/- MICE RECAPITULATES HIGH SUSCEPTIBILITY TO CHOLANGIOCARCINOMA IN PRIMARY SCLEROSING CHOLANGITIS Pinzhu Huang 1 Guangyan Wei 1 Jesse Kirkpatrick 2 MARAM ALENZI 1 Yi Lin 1 Li Tan 1 Disha Badlani 1 Li Chen 3 Mathieu Petitijean 3 Kahini Vaid 1 Shuangshuang Zhao 1 Alicia lugovskoy 1 Xin Chen 4 Gregory Gores 4 Yury Popov 1 , 1 Division of Gastroenterology and Hepatology, BIDMC, Harvard Medical School, 2 Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 3 PharmaNest, Inc, NJ, 4 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN Background: Cholangiocarcinoma (CCA) is a dreaded complication of primary sclerosing cholangitis (PSC), difficult to diagnose and associated with high mortality
While antioxidant response enzymes are well-characterized transcriptional targets of NRF2, it is recently becoming clear that NRF2 also supports cellular detoxification through metabolic rewiring to support the antioxidant systems
Understanding this connection is what makes bioregulator peptides targeting the pineal gland so compelling for both sleep optimization and longevity
Features: Published, peer-reviewed research demonstrated superior cellular absorption
