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Now, aside from the fact that the EPIC Study lead investigators screwed up royally by (a) falsely assuming they could use minimum measurements on a species-wide basis without any scientific evidence to support such a thing, and (b) picking three minimum measurements which, for several of the breeds in the study, were of normal-sized hearts rather than enlarged ones, nonetheless their goal was commendable - to recruit only dogs with enlarged hearts

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In addition, the increasing of oxidative and nitrosative stress in the heart during aging and the decreasing of hydrogen sulfide (H 2 S) concentration along with a decline of a constitutive synthesis of nitric oxide (NO) collectively lead to the dysfunction of mitochondrial mechanisms, in particular to the formation of a non-selective channelsthe mitochondrial permeability transition pores (mPTP) in the high-conductance mode, which is the cause of many pathological conditions (Strutynska et al., 2016