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All experiments were approved by the Ethics Committee of the Plastic Surgery Hospital (Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

In May 2022, Pfizer announced data from two pivotal trials of the selective sphingosine 1-phospate (S1P) receptor modulator

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Growth factor signaling, particularly involving pathways linked to vascular endothelial growth factor (VEGF) and fibroblast activity, appears to promote cell migration, collagen formation, and tissue regeneration

Safety signals of special interest, including pancreatitis, gallbladder events, neoplasms, and suicidal ideation, were adjudicated by blinded expert committees