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Science 2014;344:630-4

The failure of these treatments to restore function and slow functional disease progression can be traced to their inability to correct the underlying cause of the dysfunction- diminished synaptic connectivity among neurons in the striatum and neuronal loss in the substantia nigra (SN)

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BlastP searches across different spirochaetes genomes showed that plant-like TyrAs are restricted to the order Spirochaetales, and absent in Leptospirales, Brevinematales, and Brachyspirales (Figure S5

Our previous studies have demonstrated that endogenous DA and DA-dependent neurodegeneration have a pathophysiologic role in sporadic as well as familial form of PD