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In the target tissue, recruited phagocytic cells are activated (Xu et al

Strikingly, already basal ferroptosis-specific phospholipid peroxidation products, including oxidized PUFA-PE species, were elevated in stickers and further increased upon RSL3 treatment, while both, the basal amounts and the specific induction of these products, were markedly decreased in floaters (Fig

While targeting non-growing Mtb within the caseous centers of granuloma is being actively pursued in the TB field 118,119,120,121,122 , the heterogeneity of the host macrophages (AM, IM, and BMDMs) and its impact on bacterial physiology and drug tolerance is only recently been getting attention

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